
Goal of my longevity experiments
Do not replicate for your own safety
Educational only
I learned the hard way that biologies differ. This page is for inspiration and information, not a prescription. Learn from the approaches I took, not necessarily what I do today. Your genes, daily life, and desires may be totally different.
My goal is a poor person's longevity protocol for real life. I want cheap, everyday tools that still help healthy aging under sleeplessness, high stress, and only a few hours a week for exercise. Family holidays where you don't know what you'll eat count too. So do life transitions when you have little emotional energy left to control anything at all. I believe that under any circumstance, you may make life a bit better, even with limited resources. My life is chaotic too. I don't prioritize longevity most weeks, and I think that makes me a useful example.
Real life first, not a perfect protocol
Sleep loss, skipped workouts, social meals, and weeks when longevity slides to the back burner: that is the test bench, not the exception.
Everything is a bet
After 25 years reading PubMed and experimenting on myself, many interventions look insignificant in hindsight. I treat what I do now the same way.
Feeling alive beats feeling robotic
If a habit feels artificial, I won't keep it. I fuse interventions with emotion and social life, and skip anything I couldn't imagine doing the same way in 10 or 15 years.
My past and personal reasons for longevity
Few talk about this, yet drives matter
I was an obese kid, anorexic at 13, pursued amateur bodybuilding from 14 to 22, then burned out from controlling 30+ factors in my diet. That led me to search for a real, social, humane way of eating, and to develop my own method now called NodietXP. At 26 I was already reading about aging and anti-aging; I remember downloading an Excel sheet of 40 mechanisms of aging back then. One of the first things I did directly for healthy aging was taking supplements: berberine, tocotrienols, and astaxanthin. On the surface, I already realized I am aging. My deepest reason was simpler: raised as an emotionally neglected child, I felt I'd lost my teens and much of my twenties to mistakes and disconnection. I wanted those years back. Wanting back some years is one of the most frequent reasons I hear from others too.
I still eat cake and drink coffee every day
I'm still the chubby kid inside who dreamed of cake daily. Movement follows desire, not guilt. Night-owl creative hours disrupt my circadian rhythm, but immersion in work I love is worth more to me right now.
Social eating is non-negotiable
When someone cooks for me, I eat it. Longevity is a priority, but helping people, creating, and being with those I love rank higher. Healthy aging, for me, means finding moments to feel really alive: staying real, eating real, being real.
Borrowing freedom from earlier life stages
Since 26 I've tried to integrate something from every life stage: half-days with no responsibilities, weekend siestas, teen-like emotional freedom. That fights social and psychological aging when responsibilities multiply and others depend on you.
Longevity doesn't make you bulletproof
I've seen longevity enthusiasts die young. Life stays uncontrollable. I'm only fully in charge for parts of my day; other hours belong to other people's needs. That honesty keeps this humane.
Blaize's longevity gameplan:
Experiments for real life.
Life first, longevity second.
What is my story?
Tried all shapes and sizes
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Snapshot of my results
2026 March: After year of insomnia and high stress
A quick visual overview before the deeper story. Chronological age at testing: about 38.7 years. Context matters: sleep-onset insomnia, irregular sleep, chaotic schedule, real-life stress.
Blood-biomarker clocks
Mortality-risk models from standard blood work (PhenoAge and Bortz age use the same kind of math, different marker panels).
38.7
Chronological age
years at testing · baseline for comparison
25.4
PhenoAge
years · ~13 years below chronological
26.3
Bortz age
years · UK Biobank-trained panel
0.68
DunedinPACE
aging ~0.68 years per calendar year
35.0
OMICm Age (whole-body epigenetic)
36.9
VO2 max mL/min/kg (CPET, March 2026)
Top 1%
Arterial elasticity (despite varicose veins)
These numbers don't tell one story. The sections below explain why blood clocks, epigenetic clocks, and pace-of-aging tests can disagree, and what I do with that.
Managed weeks of insomnia with
A flexible weekly gameplan
Even when I had trouble falling asleep before 1–2 AM, I countered stress with daily experiences that gave me order through routine, real joy and social connection, and some breakthroughs, not a rigid protocol.
Go-all-out Mon
Coaching & Creative Tue
Lighter Wed
Coaching & Gym Thu
Non-stop Coaching Fri
Withdrawn Sat
Social Sun
📊 Progress I made
Markers and strength
Improved blood biomarkersImproved strength✨ How life got better
Because progress and good experiences
Genuine moments of joyFeeling more in controlSafeguards holding me backNot losing emotional centreFired up by passionRoom for peace amidst chaosTried to fill my day with
Good experiences for longevity and aliveness
Why this works
During a sleepless year I wasn't trying to erase stress, I was trying to protect longevity while still living. Small daily experiences (routine anchors, genuine joy, social connection, breakthrough workouts) let me move biomarkers and stay emotionally alive at the same time. These seven are what that looked like in practice.
Romantic Wednesday brunch
Daily challenge
Midweek is lighter, but you still want something indulgent that doesn't derail the week.
Turning it into a good experience
Whole-wheat croissant, various cheeses (Maasdam, gouda, mozzarella), hummus, cold meat cuts (Italian salami). End with coffee with 1 tsp glycine and a pinch of cocoa/cinnamon.
What I prefer
Quality over quantity: a composed plate, eaten slowly, with coffee as a ritual close.
Why this works
Joy and social connection stay in the plan. Glycine and cinnamon soften the glucose spike without making brunch feel like a diet.
Meal replacement on the road
Daily challenge
Overscheduled days or travel: no time for a proper meal, but you still need protein and fiber.
Turning it into a good experience
1.5 scoops mixed protein powder (25% whey, 30% hemp seed [50g protein/100g], 25% walnut [45g protein/100g], 20% collagen), 40g oat flakes, ginger, 1 tbsp grape skin powder, 1 tsp pumpkin seeds, 1 tbsp chia seeds, 5g glycine, pinch of ginger. (Ground rosehip seed and barley grass powder stopped because of high vitamin A levels.)
What I prefer
One shaker, one recipe: no decisions when tired.
Why this works
Mixed protein sources, fiber, and polyphenols in one portable ritual. Better than skipping food or grabbing random snacks.
Supplement staples at breakfast
Daily challenge
Many supplements, limited mental bandwidth, so it is easy to forget or overcomplicate mornings.
Turning it into a good experience
Only with breakfast: 2,000 IU vitamin D3, 1,000 mcg vitamin K-1, 250 mg PABA, 125 mg pantothenic acid, 375 mg vitamin C, 100 mcg L-selenomethionine, 300 mg rhodiola rosea extract (9 mg rosavins, 3 mg salidrosides), 18 mg astaxanthin (later decreased to 8 mg), 900 mg diosmin and 100 mg hesperidin, 1 capsule B-complex (300 mg ascorbic acid, 7.5 mg thiamine mononitrate, 8.5 mg riboflavin, 100 mg niacinamide to increase NAD, 10 mg pyridoxine HCl, 333.5 mcg folic acid, 30 mcg cyanocobalamin, 150 mcg biotin, 50 mg calcium d-pantothenate, 75 mg choline bitartrate, 75 mg inositol, 7.5 mg PABA), 600 mg TMG.
What I prefer
Anchor everything to the first meal: one moment, one stack.
Why this works
Fat-soluble vitamins and rhythm-supporting adaptogens pair with food. One anchor beats scattering pills across the day.
Antioxidants on non-workout days only
Daily challenge
High-dose antioxidants may help longevity, or blunt the hormetic stress from exercise.
Turning it into a good experience
On non-workout days only: R-alpha-lipoic acid (3×150 mg), NAC (2×600 mg), vitamin C (2×500 mg), 1×100 IU vitamin E (alpha-tocopherol, mixed tocopherols break me out).
What I prefer
Intermittent intake so the body doesn't fully adapt and down-regulate its own antioxidant enzymes.
Why this works
Workout days keep exercise-induced hormesis intact. Rest days get extra support without a daily blanket that may work against training.
Street workout with best friend
Daily challenge
Gym time is scarce; training alone feels like another obligation.
Turning it into a good experience
Street workouts in the sun (50+ SPF sunscreen) with G-Flex, aqua bags, power bands, balance board. 3 sets of each exercise (starting out, peak, last set all-out), occasional single sets with 1–3 forced reps. Exercise choice spontaneous, decided together, always trying new moves. 15 min walk or dance-boxing warmup, 10 min walk cooldown.
What I prefer
Play and novelty over a fixed program; social energy carries the session.
Why this works
Sun, friendship, and variety make breakthrough workouts sustainable. Forced reps stay rare and intentional, not daily grind.
Stress control by scheduling rules
Daily challenge
Four responsibilities plus coaching: calendar creep eats recovery and focus.
Turning it into a good experience
Scheduled appointments only Mon–Tue and Thu–Fri. No scheduled appointments between noon and 3 PM. Maximum 8 hours of concentrated effort (work or workouts) per day, focus on breakthroughs, not time spent. Every goal-oriented effort counts as work. Low-effort work (farmer's market, household chores) stays in the plan without guilt.
What I prefer
Protected midday window and capped daily intensity.
Why this works
Boundaries create predictable recovery. Breakthrough focus beats heroic hours that borrow from sleep and biomarkers.
Hack for little sleep ahead
Daily challenge
Some nights I know I only have five or six hours before the alarm. If I go straight from work to bed, my head keeps running and the sleep I get is thin.
Turning it into a good experience
First, a thirty-minute walk: enough to let off steam and settle cortisol and blood sugar, not enough to become another stressor. It marks the end of work and activity for the day. Then a warm shower at home. When the lights go off, I sit on the bed for twenty to forty-five minutes of meditation mixed with daydreaming, feeling the day as it was so emotions can finish their arc instead of chasing me into sleep. If time is really tight, one puff of sublingual melatonin spray, never more than two or three nights a week. Melatonin is not a sleeping pill; it resets circadian rhythm and can make insomnia worse if you lean on it too often.
What I prefer
A closing ritual over a rigid bedtime. Walk, shower, emotional landing, then sleep, usually deep once my nervous system gets the message that the day is actually over.
Why this works
Short sleep becomes survivable when the body and mind get a real off-ramp. The walk handles physiology, the quiet time handles what the day left unfinished, and melatonin stays a rare nudge, not a crutch.
Swipe left or right · seven experiences
What it looked like in real life
Meals and workouts
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When blood clocks disagree with epigenetic clocks
PhenoAge, Bortz age, OMICm Age, Symphony Age, and DunedinPACE
I took blood work for PhenoAge and Bortz age just days before a TrueDiagnostics TrueAge test (still high stress and sleep-onset insomnia). Chronological age: 38.7 years. The numbers told different stories.
Three kinds of question
Odometer clocks (PhenoAge, Bortz age, OMICm Age): how much accumulated mortality-risk do I resemble today. Speedometer (DunedinPACE): how fast am I aging right now. Organ map (Symphony Age): which systems drive that risk. None is ground-truth biology, all are outcome-trained proxies. Poor sleep and chaotic bedtimes may explain why epigenetic markers (like those for CRP) looked worse, even while my blood CRP remained very low. Best next step: retest after resolving chronic insomnia.
PhenoAge & Bortz age
My results
PhenoAge 25.4 years. Bortz age 26.3 years. Both more than 13 years below chronological age, despite an unfavorable life situation.
In context of other tests
Blood hs-CRP was often below lab detection (0.08 mg/L), yet CRP methylation later sat at the 85.6th percentile. OMICm Age 35.0 looked far less dramatic. Blood and epigenetic inflammation signals diverged.
What this metric measures
A mortality-risk model expressed in years: clinical biomarkers are combined in a survival model trained against mortality risk, then transformed into an age-like scale. PhenoAge (Levine 2018) uses 9 markers; Bortz age (2023, UK Biobank ~306k) uses 25. Both are risk-calibrated biological-age proxies, rather than mechanism-level measures of aging. Further reading:
OMICm Age (whole-body proxy)
My results
OMICm Age 35.0, only 3.7 years younger than chronological 38.7. I thought blood metrics meant ideal results, epigenetic whole-body age proxy was far more modest.
In context of other tests
PhenoAge/Bortz age suggested ~13 years young; OMICm suggested ~4. DunedinPACE 0.68 still looked strong. Sinlge measurement only, repeat needed to know if pace is stable over time.
What this metric measures
OMICm Age is a biological-age clock trained on clinical, proteomic, and metabolomic data. Because these multi-omic signals are captured using epigenetic biomarker proxies, the measure can be calculated entirely from DNA methylation. It highlights your overall trajectory, but it does not capture every single biological mechanism causing your body to age. Further reading:
Symphony Age (by organ)
My results
Inflammation organ age 40.6 at chronological 38.7. Liver 32.8, lungs 32.4. Heart 41.1, hormones 40.0, immune 40.5, metabolism 35.8, kidneys 37.2. Younger organs mixed with older ones.
In context of other tests
Blood hs-CRP was very low, while the methylation-derived CRP signal was substantially higher. This illustrates they may capture different aspects of physiology. Sleep and stress might be involved as well, but a single measurement cannot establish the reason.
What this metric measures
Physiological system-specific aging metrics apply blood DNA methylation to map aging across several physiological systems. Instead of reducing health to one global number, it identifies where specific aging trajectories are concentrated by linking methylation to system-specific clinical risk. Answers "where are aging-associated trajectories present?" rather than one "how old is the body or an organ?". They reflect a snapshot at a point in time. Further reading:
DunedinPACE
My results
DunedinPACE 0.68: aging ~0.68 years per calendar year. Would rank in roughly the top 30 at Rejuvenation Olympics if maintained across repeated tests. I've only tested once.
In context of other tests
Strong pace despite modest OMICm Age and mixed Symphony age physiological system-specific. The divergence is interesting, but it does not by itself establish whether differences in sleep, inflammation or other factors explain the results.
What this metric measures
A speedometer, not an odometer: DunedinPACE was trained against approximately 20 years of within-person change across 19 biomarkers of organ-system integrity at ages 26, 32, 38 and 45 in the Dunedin cohort, then distilled into a single blood DNA-methylation measurement. 1.0 = typical pace; 0.68 = 32% slower estimated pace than population average. Answers "how fast am I aging right now?"
Swipe left or right · four clock types
Physical assessment in detail
CPET, elastography, EEG · March 30, 2026
Valid maximal treadmill CPET, stopped for central fatigue. Stands alone from blood and epigenetic clocks: what my body can do under load today.
36.9
VO2 max mL/min/kg · good for age 38
114
Max ventilation L/min
177
Max heart rate bpm · 97% HRmax
14 km/h
Peak treadmill speed
14.1
Post-test lactate mmol/L
<126
Zone 2 HR target · main training gap
Breathing & upper airway
What my results mean
Peak breathing rate 46/min is healthy. Erratic warm-up breathing (20→10→20/min at 0 km/h) matches untreated upper-airway resistance: deviated septum, allergy, or obstruction. ti/ttot ~46–50% at peak signals mechanical inefficiency under load. Tidal volume ~2.47 L at peak is excellent; ventilatory reserve remains.
Diagnostician's suggestions for me
Diaphragm training: 5–10 min daily abdominal breathing, 4 sec inhale / 8 sec resisted exhale, core-stable breathing in planks. Nasal breathing in Zone 1–2. ENT/allergy evaluation if recovery worsens. Nighttime airway resistance may fragment deep sleep and blunt parasympathetic recovery.
Aerobic base vs anaerobic strength
What my results mean
Lactate threshold ~160 bpm: I jump anaerobic quickly. Absolute VO2 3103 mL/min beats VO2/kg because 37 kg muscle mass (44.8%) weighs the ratio down. RER 0.82 at rest fits a fat-dominant metabolism. Post-load BP 160/50 mmHg and strong HR recovery show cardiovascular resilience with mild parasympathetic fatigue.
Diagnostician's suggestions for me
3–4× weekly 45–60 min Zone 2 (<126 bpm, <8 km/h) to push VT1 up. HRV-guided training: if morning RMSSD is >8–10% below 7-day average, only Zone 1–2 or full rest. More generic "train harder aerobically" could worsen autonomic fatigue right now.
EEG, autonomic balance & elastography
What my results mean
Resting brain waves excellent once settled; early restlessness reflected work and home mental load. Alert EEG pattern consistent with chronic cognitive fatigue: impatience, focus problems after long workload. Parasympathetic fatigue is not simple sleep debt but chronic cognitive load plus upper-airway obstruction limiting deep sleep phases.
Elastography overall 0.79 with cardiovascular 0.82 despite varicose veins; arterial elasticity top 1%, likely from exercise and supplements. Elevated peripheral O2 consumption: mesomorph muscle mass may outpace capillary density, so each fiber gets less capillary supply.
Low blood pressure noted: maintain hydration. Normal coronary circulation signals on non-invasive tests.
Diagnostician's suggestions for me
Three-level plan: (1) HRV-guided periodization as above. (2) Vagal tone without default cold plunge: ~5–6 breaths/min for 5–20 min daily; 15 min post-workout mindfulness lying down; power naps 2–3× weekly. (3) Treat upper-airway obstruction as a sleep and autonomic priority. Light activity 2× weekly 45+ min for capillarization. Find activities with no self-expectations to break daily cognitive load.
Swipe left or right · three assessment themes
Check back often.
Updating as life changes.
Scroll down for core strategy and genetic data.
Hard lessons learned
25 years of self-experimentation
Swipe through six lessons that shaped how I think about stress, diet, supplements, medicine, and the mind-body link.
Skip every stress source one day per week
What I did
I tried daily fasted walks in bodybuilding years and daily intermittent fasting in 2008. My father walked 1.5 hours uphill every day after retiring, refusing rest days.
Honest mistakes
Within weeks my ankle hurt. Daily intermittent fasdting after a few months worsened body composition, hair, hunger, blood markers, and motivation. Dad's hip pain led to hip replacement surgery, lengthy hospitalization to treat deep-vein thrombosis triggered progressing dementia.
Hard lesson learned
Escape one day per week from any daily stress: screens, workouts, fasting, anything cumulative. Hidden wear adds up even when each day feels fine.
Fad diagnoses and treatments are everywhere
What I did
At 21–22, fighting cystic acne, I tested for intestinal worms, heavy metals, and obscure markers, sending samples abroad while working night shifts at an internet café.
Honest mistakes
I feared gluten, carbs, fats, then protein. I paid heavily for tests the medical community did not support, and built anxiety on negative results I didn't trust.
Hard lesson learned
When tests came back negative, I still had to choose hard science over the mental prison I'd built. I warn clients about anxiety-driven testing today.
Trendy diets may not match your genetics
What I did
I chased dietary advice from fitness magazines. My test case was low-carb Paleo in 2008–2009: felt good for weeks, then fatigue, no training, rising LDL and morning glucose.
Honest mistakes
I assumed the trend was right for everyone. DTC genetics later showed mixed insulin genes and protective triglyceride alleles, like my father who thrives on bread. I always felt better on higher carbs.
Hard lesson learned
Trust your experience first, use labs to confirm or challenge it, not magazine fashions. Keto was my lesson vehicle, not the universal moral.
Psychosomatic disease is real, I didn't believe it until I lived it
What I did
Cystic acne from age 16: isotretinoin three times for 6–12 months, always returning within a year. At my most desperate I ate parboiled rice, vegetables, and water, eating little every other day, losing 10+ kg of mostly muscle. Symptoms diminished but never stopped.
Honest mistakes
I didn't believe psychosomatic explanations until a universtiy professor described a case of acne clearing after rebuilding trust. In therapy I uncovered deep anger from emotional neglect. Letting it out through training and honest social moments, acne faded in 3–4 months.
Hard lesson learned
Emotional states mirror nervous system activity and can distort local body function. Weak-point organs matter. My skin has never been that reactive since. I still get spots when overstressed, skin stays my barometer, not proof that psychology replaces medicine.
Supplements work better 4–5 days per week
What I did
I ran daily supplement stacks for years. Some staples stay daily, others I now cycle. I take no supplements 1–2 days per week.
Honest mistakes
Even harmless B-complex lost its energy surplus feeling within 3–4 weeks of daily use. Panax ginseng felt flat with continuous use despite traditional cycling advice.
Hard lesson learned
Rest days guard against unknown "factor X" when stacks interact. Four-five days on, two-three off can maintain contrast indefinitely. For example, cycling of panax ginseng may prevent neurotransmitter and stress-pathway adaptation, but research evidence is not definitive.
Too much of a good thing: stacking supplements for one goal
What I did
Chasing lowest blood sugar and AMPK activation, I combined berberine, alpha-lipoic acid, glucosamine sulphate, and milk thistle same-day, on top of fish oil and vitamin E that also lower glucose and thin blood.
Honest mistakes
Headaches, irritation, binge eating after ravenous hunger. Mental work became sluggish. When taking all, doses shrank to absurd fractions of capsules, so I stopped some (berberine) while take others on separate days. I ignored overlapping effect and side-effect profiles.
Hard lesson learned
Use 1–2 supplements per effect, and account for training, fasting, and diet too. Side effects are real. Stacking of side effects is not mentioned often enough as if pills combined infinitely.
Swipe left or right · six lessons
Assessments I use
Simple tools, not obsession
Enough signal to adjust without losing my life to tracking. I am not formally affiliated with any test company listed here, and they do not endorse me.
Mention of TrueDiagnostics, DTC genetics, or other brands is personal experience only, not partnership or medical recommendation.
Blood work
What I do
Once or twice yearly comprehensive metabolic panel (routine blood chemistry) plus occasional hormone panels. I calculate PhenoAge and Bortz age from results.
Surprising results
Sex hormones did swing swing when I eat too little, train too much, or stress too hard. Inflammation can run very low now. I am very proud of that because cystic acne once suggested the opposite.
My practical takeaways
Annual labs are my cheap anchor. I watch hormones when life gets harsh, not only when I feel sick.
DTC genetic testing
What I do
Sample taken in 2019. I compare SNP readouts with blood work and lived experience, never as destiny.
Surprising results
Mostly confirmation. BCO1 rs7501331 (C;T): ~32% lower beta-carotene to vitamin A conversion. I'd already found ~7,000 IU retinol equivalents daily keeps skin near perfect.
My practical takeaways
Genes reinforce experiments, they rarely replace them. Huge blind spots remain in every report.
Epigenetic testing
What I do
TrueDiagnostics TrueAge: OMICm Age whole-body, Symphony Age by organ, DunedinPACE rate. One test so far; repeat pending better sleep.
Surprising results
Blood clocks looked ~13 years young; epigenetic inflammation age looked older than chronological. CRP methylation at 85.6th percentile while blood hs-CRP was often undetectable (<0.08 mg/L).
My practical takeaways
Don't force one number to win. Retest when context changes.
Physical assessment (CPET)
What I do
Treadmill CPET with spirometry and VO2, arterial elastography, EEG stress proxies, PHAPA autonomic profiling. March 2026 baseline.
Surprising results
Despite varicose and spider veins, arterial elasticity scored top 1%. Aerobic base is the main gap, anaerobic side and absolute VO2 (3103 mL/min) look stronger than VO2/kg.
My practical takeaways
High muscle mass weighs VO2/kg down. Priority: Zone 1-2 volume and parasympathetic work, not more heroic peaks.
Family disease history
What I do
Drew a family tree: illnesses, ages of onset. Focus list: heart disease, chronic venous disease, kidney protection, dementia, baldness.
Surprising results
DTC flagged possible thyroid cancer risk, later I learned that a second cousin had battled thyroid cancer near 50, several years ago. Genetics can highlight latent risk but are not prophetic.
My practical takeaways
The simplest map I ever made. Still steers what I bother to test and what I ignore.
HRV measurements
What I do
Occasionally a free HRV app when subjective fatigue feels unclear. Rare, because "my heart feels tired" since my twenties usually matches the number.
Surprising results
Chasing a target HRV made me robotic. Leaving energy in the tank, emotional engagement, and not over-scheduling correlate with good readings without measuring all the time.
My practical takeaways
Subjective rest beats metric chasing. Mental fog means stop exertion, then reassess. Six years of living for experience, not performance, improved both.
Swipe left or right · six assessments
Targeting my weak points
Where my protocol actually focuses
Genetics and family history set the board. These are problems I manage in real life, not on a fantasy spreadsheet.
Too much willpower, sympathetic overload
The weak point
I'm bound to be too willful (leftover from obsessiveness). Years ago, I used to structure entire days by to-do lists and squeeze "my hour" at midnight without enjoying being alive. Sympathetic overload became my default.
What makes it difficult
After 2–3 intense days I keep going mechanically: I don't know what I want or feel, only that I must push. Any protocol feels like war when I'm already overburdened.
What I do as countermeasure
30–45 min walks, meditation mixed with daydreaming, spontaneous half-days with no agenda, and a lighter day after every 2–3 focused days. This helped both health markers and feeling alive. If I can just be, exercise and supplements stop feeling like resistance.
Hair loss since age 20
The weak point
Gradual thinning. Stress and blood sugar spikes are the biggest triggers for increased shedding in my case, before any topical ever matters.
What makes it difficult
Tried home dermaroller and dermapen sessions on scalp but they become just another project after ~3 months, so I only do it in bouts of 8-12 weekly sessins. No single supplement wins alone when life stays chaotic.
What I do as countermeasure
Rotate natural 5-AR supports (panax ginseng, green coffee, pumpkin seed, matcha). Copper-peptide hair water with melatonin and rosemary 3–4× weekly. A mix of caffeine, probiotic and Nizoral shampoos on workout or greasy days. Stress control first, topicals second. Dermapen cycles when I have patience, then breaks.
Skin stays my barometer
The weak point
After clearing cystic acne at 22, my skin remains sensitive. Overstress still brings zits, sebum production was always my weak link, even when anger work lowered baseline reactivity.
What makes it difficult
Too much B12, methyl donors, oleic acid(I stay away from otherwise healthy olive oil), or methionine or leucine from protein powders (even plant protein) in one meal can inflame me within days. Skin reacts before blood work catches up.
What I do as countermeasure
Low-GI carbs, fish oil, black seed oil, capped leucine at every meal, milk thistle, tocotrienols, myo-inositol, astaxanthin. Food rules plus emotional pacing keep skin near perfect most days. Spots still mean I'm overdoing something.
Varicose veins since age 14
The weak point
Like my mother at the same age, I developed spider veins on both ankles early on. I have a visible varicose vein on right calf, which I may remove medically later. Family pattern, not a surprise.
What makes it difficult
I used to chase 450 kg leg presses with bad form at 17–20. Heavy loads and low reps strain veins I already inherited. Sitting work doesn't help either.
What I do as countermeasure
Gym once weekly, 12–20 rep sets for legs using moderate weights. Street workout with metabolic stress for muscle hypertrophy instead of maximal loads. 30-45min walks for capillarization morning or evening. Diosmin and hesperidin, gotu kola extract (madecassoside-rich), pine bark extract, D3/K2, tocotrienols daily.
Swipe left or right · four weak points
My genetic makeup
DTC test readouts: informed guesses, not destiny
I treat genetic test results as educated guesses I compare with blood biomarkers and first-hand experience of how my body responds. Genes represent potentials, not biological fate. Many genes are still unknown or poorly understood, so every analysis has blind spots. What favors longevity in my plan may differ for you; this is the background I actually have.
Personal interpretation only. Not medical advice, diagnosis, or a recommendation to pursue DTC testing.
Polygenic longevity overview
Surprising findings
My readout suggests an optimized framework for healthspan, distinctively weighted toward neurovascular protection and regulated bioenergetics. Primary assets sit in sirtuin and lipid-transport cascades, alongside a fluid mitochondrial uncoupling network and wild-type homozygosity across MTOR, KL, LMNA, and APOB.
In context of other genes
This favorable baseline coexists with HDL-depressing variants and glucose-risk alleles elsewhere; longevity architecture is never one-sided. I read the whole polygenic picture, not single “good gene” headlines.
My practical takeaways
Use favorable readouts to justify investment in brain, vascular, and mitochondrial habits, not to skip blood work or assume immunity from metabolic drag.
SIRT1 (rs3758391 C;T)
Surprising findings
Heterozygous for the active SIRT1 variant: NAD+-dependent deacetylase involved in chromatin remodeling, cell survival, and DNA repair under metabolic stress. In cohorts, this allele associates with preserved cognitive function at advanced age.
In context of other genes
Pairs with CETP (rs5882) and favorable APOB/LDL mechanics; neuroprotection and lipid context reinforce each other rather than acting in isolation.
My practical takeaways
Supports NAD+-aware habits (sleep, training rhythm, not chronic over-restriction) but does not replace measuring cognition, mood, and recovery in real life.
CETP (rs5882 A;G)
Surprising findings
Heterozygous for the favored Val405 CETP variant, linked to altered lipid particle size, higher baseline HDL, and lower relative risk for neurodegenerative disorders including Alzheimer's in genetic studies.
In context of other genes
Critical counterbalance to my HDL-quantity drag (ABCA1 cluster, WWOX, NLRC5): lower volumetric HDL but potentially larger, more resilient particles via altered cholesteryl ester transfer kinetics.
My practical takeaways
Don't panic over low HDL-C alone; particle quality and LDL clearance matter more in my profile. Still track full lipids, not one number.
UCP2 & UCP3 (rs660339, rs2075577, rs659366)
Surprising findings
Highly heterozygous across uncoupling proteins: dynamic capacity for mitochondrial proton leak. Mitochondria can dissipate the gradient as heat instead of maximizing ATP, reducing ROS generation and cumulative oxidative stress.
In context of other genes
Sits in the same bioenergetic story as PPARGC1A modulators (mitochondrial biogenesis) and wild-type MTOR: a flexible, safety-valve metabolism rather than pure efficiency-at-all-costs.
My practical takeaways
Supports varied movement (walks, dance-boxing, spontaneous street workouts) over grinding one metabolic lane. Heat and easy days aren't wasted; they may be genetically compatible.
PPARGC1A (rs8192678, rs3755863)
Surprising findings
PGC-1α modulators: master regulator of mitochondrial biogenesis. rs8192678 shows age-dependent phenotype: vascular tone and lipid clearance behaviors shift between early adulthood and post-50 physiology.
In context of other genes
Interacts with UCP uncoupling and CYP7A1 bile-acid flux; metabolic pacing changes with age, not just with diet fads.
My practical takeaways
Expect protocol needs to evolve after 50. Retest blood lipids and training response by life stage, not by twenty-something memory.
Baseline anchors: MTOR, LMNA, Klotho
Surprising findings
Wild-type homodimers for MTOR (rs2536 T;T), LMNA (rs4641 C;C), and Klotho (rs9536314 T;T): no common variants for accelerated senescence or unstable nuclear envelopes in these loci.
In context of other genes
Structural and pacing genes look standard while metabolic and HDL pathways carry most of the actionable variance; baseline resilience doesn't erase downstream lipids or glucose risk.
My practical takeaways
Telomere and structural readouts aren't my worry list. Focus experiments on lipids, glucose, and lived recovery instead.
APOB & lipid clearance foundation
Surprising findings
Homozygous major alleles across APOB cluster (rs1042034 A;A, rs512535 G;G, rs676210 G;G): preserved LDL receptor binding affinity and stable cardiovascular aging foundation.
In context of other genes
Reinforces protective LDLR, LDLRAP1, and PCSK9 (rs505151 A;A) readouts; endocytic clearance axis is a strength even when HDL quantity is depressed.
My practical takeaways
Cardiovascular priority is HDL particle network and bile-acid flux, not fear of familial LDL overload from APOB structure alone.
BCO1: beta-carotene conversion
Surprising findings
rs7501331 (C;T): ~32% reduction in beta-carotene-to-vitamin-A conversion efficiency. Explains why carotenoid-heavy diets alone never fixed my skin, so I needed preformed retinol equivalents.
In context of other genes
Independent of FADS omega-3 conversion and lipid transport: a separate “plant → active nutrient” bottleneck. I stopped high-vitamin-A plant powders (rosehip, barley grass) when blood context suggested excess vitamin A risk.
My practical takeaways
~7,000 IU retinol equivalents daily (from experiments, not genes alone) keeps skin near perfect. Genes confirmed; blood and skin confirmed harder.
FADS2 cluster: omega-3 conversion
Surprising findings
Homozygous major alleles rs174577 (C;C) and rs174576 (C;C): baseline delta-6 desaturase activity associated with standard, efficient ALA → long-chain omega-3 conversion vs. reduced-capacity minor-allele carriers.
In context of other genes
All five FADS SNPs sit adjacent; literature treats them as a unit. rs174577 leads in GWAS for PUFA metabolism. Favorable conversion doesn't cancel HDL drag or glucose-risk alleles; different pathways.
My practical takeaways
Plant ALA sources are viable for me, but I still prefer mixed marine/plant intake when life is stressful; conversion potential ≠ guaranteed blood EPA status.
Glucose homeostasis overview
Surprising findings
Mixed profile: TCF7L2 heterozygosity and IDE (C;C) suggest impaired regulation and slower insulin clearance, yet SGK1 and G6PC2 minor alleles modulate acute insulin secretion capacity.
In context of other genes
FABP2 (G;G) limits post-meal fatty-acid overload that worsens insulin resistance; gut lipid handling is protective even when beta-cell genetics are mixed.
My practical takeaways
Watch fasting insulin and HOMA-IR in labs; use glycine/cinnamon coffee rituals and meal timing as experiments, not because one SNP “proved” diabetes.
TCF7L2 (rs12255372-T)
Surprising findings
Highest-impact common locus for Type 2 diabetes risk. T allele dampens Wnt signaling, affecting pancreatic beta-cell survival and insulin secretion.
In context of other genes
Partially offset by SGK1/G6PC2 secretory dynamics: spikes may trigger compensatory insulin release in my profile, masking problems until stress and sleep erode the buffer.
My practical takeaways
Sleepless weeks are the real stress test, not a single glucose reading after a perfect breakfast. Protect sleep and midday recovery windows.
IDE (rs2209972 C;C)
Surprising findings
Insulin-degrading enzyme variant slows clearance: insulin lingers longer, correlating with higher fasting insulin and upstream insulin resistance in genetic literature.
In context of other genes
Stacks with TCF7L2 risk but contrasts with favorable FABP2 fat absorption; systemic lipids aren't the main driver of my insulin kinetics; clearance and secretion genetics are.
My practical takeaways
Prefer steady meals and avoid chronic snacking that keeps insulin elevated. Intermittent fasting days are tools, not punishments; they match how my clearance behaves.
SGK1 & G6PC2 counterbalance
Surprising findings
Protective minor alleles SGK1 (rs9402571-G) and G6PC2 (rs573225-T): heterozygous status suggests optimized insulinogenic index: pancreas can secrete rapidly when glucose spikes.
In context of other genes
Explains why standard fasting glucose can look fine while IDE keeps insulin higher, but secretion compensates until it can't (stress, sleep loss, overtraining).
My practical takeaways
Measure fasting insulin, not glucose alone. Compensation is a gift with an expiration date under sleepless coaching weeks.
FABP2 Ala54 (rs1799883 G;G)
Surprising findings
Ancestral homodimer: normal, moderate intestinal fat absorption. Minimizes hypertriglyceridemia and lipid-induced insulin resistance from post-meal fatty-acid flooding.
In context of other genes
Protective counterpart to TCF7L2/IDE glucose risk and RXRA shift variants; meals rich in fat aren't automatically my insulin enemy if timing and volume stay sane.
My practical takeaways
Chicken-and-rice routine lunches fit genetics; gratuitous fat bombs don't. Still watch triglycerides in blood; genes set tendency, meals write the score.
RXRA promoter (rs3118536 A;C)
Surprising findings
Minor allele alters transcription for nuclear receptors governing cross-talk between vitamin D, fatty acid, and carbohydrate metabolic cascades: distinct response when shifting fuel sources.
In context of other genes
Integrates with PPARGC1A age-dependent pacing and UCP uncoupling; metabolic flexibility is genetically “colored,” not generic.
My practical takeaways
Big macronutrient swings need gradual transitions and biomarker checks. Romantic brunch Wednesdays work because they're intentional, not random chaos.
SHBG & CD209: not glycemic flux
Surprising findings
SHBG (rs6259 G;G) and CD209 (rs4804803 A;G) govern structural glycosylation clearance and pattern-recognition carbohydrate binding in immunity, not direct blood-sugar control.
In context of other genes
Easy to misfile under “carb metabolism” in DTC reports. Sits beside hormone panels I already run; connects genetics to sex-hormone swings under stress, not HbA1c alone.
My practical takeaways
When DTC buckets genes wrongly, I re-sort by pathway. Immune/glycosylation SNPs inform inflammation context, not meal timing rules.
HDL accumulative drag
Surprising findings
Unfavorable homozygosity/heterozygosity across rs3843763, rs183130, rs2548861 (WWOX), rs4149274 (ABCA1), rs1566439 (NLRC5): multi-locus depression of circulating HDL-C volume.
In context of other genes
CETP (rs5882) alters transfer kinetics: lower quantity but potentially larger, resilient HDL particles. Quantity and quality pull in opposite directions in my readout.
My practical takeaways
Never optimize for HDL-C alone. Track ApoB, LDL particle metrics, and how I feel on statins or plant sterols; genes predict debate, blood decides.
LDL clearance strength
Surprising findings
Wild-type LDLR (rs5927 G;G, rs14158 G;G), LDLRAP1, protective PCSK9 (rs505151 A;A, no E670G gain-of-function), and ancestral APOB architecture, with optimized hepatic LDL internalization.
In context of other genes
This is why APOB homozygosity matters as foundation; clearance mechanics are the counterweight to HDL mass issues. Cardiovascular risk framing should center ApoB/LDL, not HDL panic.
My practical takeaways
LDL-lowering strategies that preserve receptor density (lifestyle, careful pharma) align with genetics. I still verify with labs, not a genetic free pass.
CYP7A1 bile-acid synthesis
Surprising findings
Homozygous CYP7A1 (rs3808607 T;T) promoter variant: rate-limiting cholesterol → bile acid conversion. Alters baseline transcription and lipid response to plant sterols and dietary interventions.
In context of other genes
Hepatic sterol flux links HDL drag, CETP kinetics, and PPARGC1A age shifts; bile-acid pathway is a master dial, not a footnote.
My practical takeaways
Plant sterol experiments need before/after labs. What works in papers may land differently with my CYP7A1 promoter state.
Swipe left or right · nineteen genetic readouts
How is my protocol different?
Longevity interventions I do and don't, and why
Not because skipped items are bad, but because my current priorities lie elsewhere.
| ✓ What I use | – What I don't use (for now) |
|---|---|
| ✓Keeping stress within limits Two intense days, then a lighter third with unscheduled work and more social time. Six years ago I stopped burning out at the end of each day: ~30% more productive since then. I want to be present at work. No more grinding while leaving my emotional self behind. Biggest impact on markers and aliveness. | –Prescription oral longevity drugs I prefer cheaper, lower-risk tools many people can access. Some supplements I take are both sold as supplements and over-the-counter drugs (benfotiamine, ALA). No metformin: blood sugar is sometimes already too low, gentler supplements handle it. No rapamycin: I already moderate mTOR and need it for muscle growth. Higher risk than my current bets. |
| ✓Supplements by daily challenge Daily staples plus situational stacks: short sleep, large late meal, rest day vs workout day. No supplements 1–2 days per week to avoid unknown cumulative "factor X" when compounds stack. Cycling keeps contrast alive, even B-complex loses its energy surplus after 3–4 weeks of daily use. | –GLP-1 receptor agonists & research peptides From childhood obesity research I know GLP-1 can stabilize life when everything feels disempowering. For me, unnecessary. Some supplements already give me too much satiety on hard days. Synthetic peptides like BPC-157 feel high-risk: more mechanistic reasoning than solid human outcome data for my taste. |
| ✓Eating flexibly based on the day Routine meals on busy days, daily cake and coffee for joy, Saturday brunches for connection. Longevity hides in ingredients: deoiled nut flours, special berries, cocoa in coffee. All must taste great. Discovery meals at new restaurants count too: adherence only works when food stays pleasurable. | –Red light therapy panels Considered for skin aging; may try later. Researching alternatives: sunscreen filtering UVB, UVA, and visible blue light may tilt sun exposure toward red wavelengths. Not equivalent to a dosed panel, but zero extra effort beyond changing sunscreen. |
| ✓Exercise for the experience of it Max 3 aggressive workouts weekly or they become a job. Two playful street workouts, one serious gym session. A 4th hard session makes me resist breakthroughs elsewhere: creative work, hard decisions, uncomfortable conversations. Other days: 30–45 min walks to vent steam, or dance-boxing to energize. | –Hyperbaric oxygen & sauna HBOT isn't worth the time for me unless it appears at the gym I already visit once weekly. Portable steam saunas exist, but I doubt I'd use them more than once weekly. Groin icing during sauna feels too artificial. Exploring sauna vests instead, no solution yet. |
| ✓Intermittent fasting (IF) and caloric restriction woven into the week 14 hour fast 2–3× weekly when I ate late and naturally skip breakfast. Two rest days on weekends often drops appetite on day two into mild caloric deficit, craving fat over carbs. Not a rigid protocol, it follows how the week actually unfolded. | –Cold plunges & cold therapy I hate cold since childhood and feel most alive above 30°C. Anorexic-era ice showers left bad memories. Morning cool rinse refreshes but doesn't trigger adaptive cold stress. Might try cryotherapy at the gym once weekly if convenient, same as sauna in my case. |
| ✓Emotional honesty, meditation mix & daydreaming 20–45 min before sleep: feel the day as it was, attach to emotions so they complete their arc. Morning 20 min daydreaming since age 3–4. Centers me and connects to emotional needs for the day. I sleep deeply even on short nights. | –Therapeutic plasma exchange (TPE) Still investigating with an open mind. Doesn't meet my filter of "cheap and accessible to the masses" today. May revisit if evidence and access change, not a closed door. |
| ✓Topicals on face and scalp Scalp and face topicals 3–4× weekly after sweaty days: caffeine/Nizoral, rosemary + copper peptides, bakuchiol, gotu kola wash. | –Gene therapy Expensive and high risk relative to tools I can verify in blood work and daily life. Not on my list while cheaper, reversible experiments still move markers. |
| ✓Microneedling Dermapen sets (~8-10 sessions) every year on face, neck, and scalp. 20 sessions with 1.5mm dermaroller at 24 improved acne scars ~40%. | –TRT (Testosterone replacement therapy) At my age, if I keep stress at bay and don't overwork or overtrain, testosterone stays healthy. TRT is often used as a disguise for overworking, or an excuse to chase the anabolic side. I'd rather fix sleep, load, and recovery first. |
| ✓PRP and blood donation 3 PRP injections in 2024 for a hand injury (with peripheral blood mononuclear fraction). Intermittent blood donation: it helps others while also being good for high iron stores . | –PRP for vanity or joints (not yet) PRP boosted healing for a 2024 hand injury, with clear limits, not a longevity fountain. Have not tried PRP for scalp or joints, PRF untested. Intentional non-use for now. |
| ✓Environmental optimization Filtered drinking water (microplastics too). Clothes toward 100% cotton. Stainless steel pans. A/C kept filtered and clean. Investigating shower and cleaning-water filtration. Apps to filter blue light on desktop and smartphone screens. | –Wearables I've never tracked numbers constantly, wearing trackers all the time alienates me from my body. A few weeks of tracking can give insight, then I turn that into practice and stop wearing the device. Most insights come from attuning to your body. But remember: under high stress you shouldn't trust introspection. |
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Questions people ask
About Blaize's longevity gameplan
Straight answers to what people search for — and how one real-life protocol handles them.
⚠️Should I copy Blaize's longevity protocol?
No. Genetics, sleep, stress, and what you actually enjoy differ from his. This page is an experiment log for inspiration, not a prescription. Blaize's rule: steal the reasoning and the mistakes, not the supplement list or schedule. For medical decisions, work with a clinician who knows your history locally.
🧬Why do biological age tests give different results?
Because they measure different things. PhenoAge and Bortz age read blood biomarkers tied to mortality risk — an odometer of accumulated risk. DunedinPACE estimates how fast you are aging right now — a speedometer. Epigenetic clocks such as OMICm and Symphony Age react strongly to sleep loss and stress. Blaize uses all of them as useful proxies, not absolute truth. When they disagree, his first move is better sleep and retesting, not a new stack of pills.
💡Can you pursue longevity on a tight budget?
Yes, if you drop the gear-heavy model. Blaize calls his approach a poor person's longevity protocol: annual blood work, a few hours of exercise per week, one rest day from any daily stress, and meals that still work at family holidays. Joy and social eating stay in the plan — they are what make sensible rules survivable for 10 to 15 years, not enemies of healthy aging.
🏃How much exercise do you need for healthy aging?
Enough to move the needle, not enough to borrow from sleep. Blaize caps concentrated work or training at about eight hours a day, chases breakthrough workouts over heroic volume, and treats Zone 2 below roughly 126 bpm as his main gap from CPET testing. Street workouts with a friend beat lonely gym marathons because social energy carries sessions through sleepless weeks — movement follows desire, not guilt.
💊Do longevity supplements actually work?
Many look insignificant after 25 years of reading PubMed and self-experimenting. Blaize treats every pill as a bet, not a guarantee. He anchors most supplements to breakfast so nothing scatters across the day, skips high-dose antioxidants on workout days so exercise hormesis stays intact, and lets blood tests plus how he feels override influencer stacks. Supplements support the life; they do not replace it.
⏱️Is intermittent fasting required for longevity?
Not for Blaize — daily fasting became another stress injury, like daily walking did for his joints. His protocol assumes real meals, social eating, and chaotic weeks. Longevity that fights family dinners or work lunches does not survive contact with actual life. He would rather eat normally and protect sleep than win a fasting streak.
🦶Why take a rest day from healthy habits?
Because even good stress accumulates when it never stops. Blaize takes one day off per week from every repeated stress — walking, fasting, cold exposure, rigid schedules — after learning through joint injuries and his father's hip-replacement cascade. The rest day is a safety margin for biomarkers and mood, not laziness. Continuous "optimization" was how he burned out from bodybuilding at 22.
❤️Why focus on feeling alive instead of biological age?
Many people chase longevity to recover lost years or emotional freedom, not to top a leaderboard. Robotic protocols often fail because they fight identity, cake, and friendships. Blaize still eats dessert and drinks coffee daily; he measures success by aliveness and connection while clocks improve in the background. If a habit feels artificial, he will not keep it for a decade — and neither will most people.
🌙Can you improve biological age with poor sleep and high stress?
Only partly — and honesty matters. Blaize ran much of this experiment during a sleepless year with four jobs and a newborn. Epigenetic clocks worsened; blood clocks stayed mixed. His response was not more rigidity but small good experiences: protected midday breaks, a closing ritual before short sleep, and habits that fit chaos. Perfect sleep first is ideal; realistic wins under stress are what this page documents.
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